Hydrodynamic Cavitation in Pharmaceutical Particle Engineering, Crystallization, and Drug Delivery

Bibliography

[1] Kozyuk OV. Hydrodynamic Cavitation for Pharmaceutical Particle Management and Drug Delivery. May 2026. p. 1-21. doi: 10.13140/RG.2.2.32648.58884.

[2] Rayleigh L. On the pressure developed in a liquid during the collapse of a spherical cavity. Philosophical Magazine. 1917;34:94-98.

[3] Brennen CE. Cavitation and Bubble Dynamics. New York: Oxford University Press; 1995.

[4] Gogate PR, Pandit AB. Hydrodynamic cavitation reactors: a state of the art review. Reviews in Chemical Engineering. 2001;17(1):1-85.

[5] Panda D, Saharan VK, Manickam S. Controlled hydrodynamic cavitation: a review of recent advances and perspectives for greener processing. Processes. 2020;8(2):220. doi: 10.3390/pr8020220.

[6] Noyes AA, Whitney WR. The rate of solution of solid substances in their own solutions. Journal of the American Chemical Society. 1897;19(12):930-934.

[7] U.S. Food and Drug Administration. Liposome Drug Products: Chemistry, Manufacturing, and Controls; Human Pharmacokinetics and Bioavailability; and Labeling Documentation. Guidance for Industry. 2018.

[8] U.S. Food and Drug Administration. Drug Products, Including Biological Products, that Contain Nanomaterials. Guidance for Industry. 2022.

[9] International Council for Harmonization. ICH Q8(R2): Pharmaceutical Development. 2009.

[10] International Council for Harmonization. ICH Q9(R1): Quality Risk Management. 2023.

[11] International Council for Harmonization. ICH Q10: Pharmaceutical Quality System. 2008.

[12] International Council for Harmonization. ICH Q13: Continuous Manufacturing of Drug Substances and Drug Products. 2022.

[13] U.S. Food and Drug Administration. PAT: A Framework for Innovative Pharmaceutical Development, Manufacturing, and Quality Assurance. Guidance for Industry. 2004.

[14] U.S. Food and Drug Administration. Process Validation: General Principles and Practices. Guidance for Industry. 2011.

[15] Lombardo D, Kiselev MA. Methods of liposome preparation: formation and control factors of versatile nanocarriers for biomedical and nanomedicine applications. Pharmaceutics. 2022;14(3):543. doi: 10.3390/pharmaceutics14030543.

[16] Alshaer W, Nsairat H, Lafi Z, Hourani OM, Al Kadash A, Esawi E, Alkilany AM. Quality by Design approach in liposomal formulations: robust product development. Molecules. 2023;28(1):10. doi: 10.3390/molecules28010010.

[17] Microfluidics. Microfluidizer Processors: Technology and Applications. 2008.

[18] Panagiotou T, Mesite SV, Auer JG, Fisher RJ. Nanoencapsulation Using the Microfluidizer Technology Platform. Supplied corporate technical presentation.

[19] Microfluidics. Penicillin Suspension: Materials Processing Data Sheet. Reference BP21099900. 2005.

[20] Microfluidics. Ophthalmic Suspension: Materials Processing Data Sheet. Reference BPEH87920. 2005.

[21] Microfluidics. 25% Drug Slurry for Oral Delivery: Materials Processing Data Sheet. Reference BPY99093-1. 2005.

[22] Microfluidics. Liposomes Containing a Drug for a Topical Cream: Materials Processing Data Sheet. Reference BPS97918-1. 2008.

[23] Microfluidics. Liposome and Vitamin E Mixture: Materials Processing Data Sheet. Reference CSEH96964-1. 2008.

[24] Microfluidics. BioPharmaceutical Formulations: Microfluidizer Processor for Use in the Biotech and Pharmaceutical Industries. 2008.

[25] Panagiotou T, Bernard JM, Mesite SV. Nanoemulsions Using Microfluidizer Technology. Technical report. 2005.

[26] Panagiotou T, Mesite S, Fisher R, Gruverman I. Production of Stable Drug Nanosuspensions Using Microfluidics Reaction Technology. NSTI Nanotech 2007. 2007;4:246-249.

[27] Microfluidics. PureNano Continuous Crystallizer: A Breakthrough in Crystallization Technology Enables Continuous Manufacturing of Nonsoluble Drug Suspensions. 2011.

[28] Felmet K, Olsofsky M, Robertson S, Starbuck C, Tom J, Tung HH, Wang J. An Evaluation of Cavitation Milling to Achieve Particle Size Reduction of Active Pharmaceutical Ingredients. Presented at the AIChE Annual Meeting; 2001; Reno, Nevada.

[29] Kozyuk OV. Hydrodynamic Cavitation Crystallization Process. U.S. Patent 7,041,144 B2. Issued May 9, 2006.

[30] Kozyuk OV, Myerson AS, Weinberg R. Hydrodynamic Cavitation Crystallization Device and Process. U.S. Patent 7,314,516 B2. Issued January 1, 2008.

[31] Kozyuk OV. Device and Method for Creating Hydrodynamic Cavitation in Fluids. U.S. Patent 6,502,979 B1. Issued January 7, 2003.

[32] Kozyuk OV. Method and Apparatus for Producing Ultrathin Emulsions and Dispersions. U.S. Patent 5,931,771. Issued August 3, 1999.

[33] IDEX Material Processing Technologies, Microfluidics. Microfluidizer High Shear Homogenizer Technology. Official website.

[34] IDEX Material Processing Technologies, Microfluidics. Microfluidizer Technology for Pharmaceutical Industries. Official website.

[35] IDEX Material Processing Technologies, Microfluidics. Microfluidizer Interaction Chambers. Official website.

[36] U.S. Food and Drug Administration. Sterile Drug Products Produced by Aseptic Processing: Current Good Manufacturing Practice. Guidance for Industry. 2004.

[37] International Council for Harmonization. ICH Q2(R2): Validation of Analytical Procedures. 2023.

[38] International Council for Harmonization. ICH Q14: Analytical Procedure Development. 2023.

[39] IDEX Material Processing Technologies, Microfluidics. Scalable High Pressure Homogenizing Technology: How Microfluidizer Technology Scales. Official website.

[40] Swain S, Tiwari V, Ranade VV. Hydrodynamic cavitation induced breakage of carbamazepine dihydrate crystals: experimental insights and modeling. Industrial & Engineering Chemistry Research. 2025;64(42):20362-20375. doi: 10.1021/acs.iecr.5c02950.

[41] Tiwari V, Walker G, Ranade VV. Particle breakage using wet mill, ultrasonic, and hydrodynamic cavitation. Crystal Growth & Design. 2023;23(12):8620-8636. doi: 10.1021/acs.cgd.3c00756.

[42] Kozyuk O. Hydrodynamic Cavitation. [Unpublished technical manuscript and supporting data] 2026.